Source:http://linkedlifedata.com/resource/pubmed/id/18633164
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2008-7-17
|
| pubmed:abstractText |
Efficient reproduction using natural mating and reproduction technology [in vitro fertilization (IVF) and embryo transfer (ET)] was investigated in IRS2 deficient mice with C57BL/6JJcl genetic background (Irs2(-/-) mice) as a typical type 2 diabetes model. From the results using various combinations of Irs2(-/-) and Irs2(-/+) mice, the combination of female Irs2(-/+) x male Irs2(-/-) was found to be more efficient than other combinations. In applications of reproduction technology using IVF and ET, the combination of female Irs2(-/+) x male Irs2(-/-) involves the possibility of Irs2(-/-) production by repeats using female Irs2(-/+) mice. However, reproductive continuity using this combination is difficult because of dependence on human technique and the cost of ET. Therefore, we concluded that Irs2(-/-) mice should be produced by embryo transfer using Irs2(-/-) mice from a colony consisting of female Irs2(-/+) x male Irs2(-/-).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1341-1357
|
| pubmed:author |
pubmed-author:AraiToshiroT,
pubmed-author:EtoTomooT,
pubmed-author:HashimotoHaruoH,
pubmed-author:HatakeyamaTeruhikoT,
pubmed-author:HiokiKyojiK,
pubmed-author:HoyaNaokoN,
pubmed-author:ItoMamoruM,
pubmed-author:KadowakiTakashiT,
pubmed-author:KamisakoTsutomuT,
pubmed-author:KosakaKinoriK,
pubmed-author:KubotaNaotoN,
pubmed-author:NomuraTatsujiT,
pubmed-author:OhnishiYasuyukiY,
pubmed-author:OhsugiMitsuruM,
pubmed-author:SaitoMuneoM,
pubmed-author:SuzukiRyoR,
pubmed-author:TamaokiNorikazuN,
pubmed-author:TobeKazuyukiK,
pubmed-author:UeyamaYoshitoY,
pubmed-author:YamauchiToshimasaT,
pubmed-author:YokosukaMakotoM
|
| pubmed:issnType |
Print
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
407-11
|
| pubmed:meshHeading |
pubmed-meshheading:18633164-Animals,
pubmed-meshheading:18633164-Diabetes Mellitus, Type 2,
pubmed-meshheading:18633164-Embryo Transfer,
pubmed-meshheading:18633164-Female,
pubmed-meshheading:18633164-Fertilization in Vitro,
pubmed-meshheading:18633164-Male,
pubmed-meshheading:18633164-Mice,
pubmed-meshheading:18633164-Mice, Inbred C57BL
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
An Efficient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background.
|
| pubmed:affiliation |
Central Institute for Experimental Animals, Kanagawa, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|