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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-9-29
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pubmed:abstractText |
Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception and targets of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pain in diabetes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18633115-10204728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18633115-10339595,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2801-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18633115-Animals,
pubmed-meshheading:18633115-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:18633115-Blood Glucose,
pubmed-meshheading:18633115-Body Weight,
pubmed-meshheading:18633115-Chromatography, High Pressure Liquid,
pubmed-meshheading:18633115-Diabetes Mellitus, Experimental,
pubmed-meshheading:18633115-Ganglia, Spinal,
pubmed-meshheading:18633115-Immunoblotting,
pubmed-meshheading:18633115-Inosine,
pubmed-meshheading:18633115-NF-kappa B p50 Subunit,
pubmed-meshheading:18633115-Pain,
pubmed-meshheading:18633115-Pain Measurement,
pubmed-meshheading:18633115-Phenanthrenes,
pubmed-meshheading:18633115-Rats,
pubmed-meshheading:18633115-Salicylates,
pubmed-meshheading:18633115-Sciatic Nerve,
pubmed-meshheading:18633115-Sulfasalazine,
pubmed-meshheading:18633115-Tandem Mass Spectrometry
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pubmed:year |
2008
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pubmed:articleTitle |
Sulfasalazine blocks the development of tactile allodynia in diabetic rats.
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pubmed:affiliation |
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. lnb@case.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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