Linked Life Data

18631320

Source:http://linkedlifedata.com/resource/pubmed/id/18631320

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-10-6
pubmed:abstractText
This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for in-depth analysis. This year, the first quantitative estimate of evolutionary conservation of genetic effects on lifespan has pointed to the key importance of genes involved in protein synthesis, a finding confirmed and extended by experimental work. Work in Caenorhabditis elegans and Drosophila has highlighted the importance of phase 2 detoxification in extension of lifespan by reduced insulin/Igf-like signalling. Thorough characterization of systems for dietary restriction in C. elegans is starting to show differences in the mechanisms by which these interventions extend lifespan and has revealed a requirement for autophagy. The response to heat shock in C. elegans turns out to be systemic, and mediated by sensory neurons, with potentially interesting implications for the response of lifespan to temperature. Work in Escherichia coli and yeast has revealed a role for retention of aggregated proteins in the parent in the rejuvenation of offspring while, as in C. elegans, removal of the germ line in Drosophila turns out to extend lifespan. Aging research has suffered the loss of a great scientific leader, Seymour Benzer, and his trail-blazing work on aging and neurodegeneration is highlighted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1474-9726
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
605-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Some highlights of research on aging with invertebrates, 2008.
pubmed:affiliation
Institute of Healthy Ageing and GEE, UCL, London, UK. l.partridge@ucl.ac.uk
pubmed:publicationType
Journal Article, Review