Source:http://linkedlifedata.com/resource/pubmed/id/18628436
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2008-7-16
|
| pubmed:abstractText |
Thrombocytopenia has been reported as a valid surrogate for liver cirrhosis and could be used to identify groups at high risk of hepatocellular carcinoma (HCC) for ultrasonographic (US) screening. We designed this two-stage community-based screening for HCC. In 2004, subjects (ages > or =40 years) were invited to undergo comprehensive health examinations, with 17,551 men (ages 63.0 +/- 11.5 years) and 39,151 women (ages 59.9 +/- 11.7 years) participating. Subjects with platelet counts <150 x 10(9)/L or alpha-fetoprotein (AFP) >20 ng/mL were enrolled for the second-stage US screening; 3,242 subjects (5.7%; male/female, 1,415/1,827; age 66 +/- 10 years) were candidates for US screening and 2,983 (92.2%) responded. Of 137 suspected cases, 124 (90.5%) complied with referral for confirmation and 72 (58.1%) were confirmed to be HCC cases (male/female, 41/31; age 68.1 +/- 8.8 years). Screening with AFP, thrombocytopenia, or both could identify 0.64% (n = 364), 5.33% (n = 3,205), and 5.7% (n = 3,242) of the high-risk subjects from the population, estimated to include 50.5%, 54.5%, and 71.3% of all HCC cases. Among confirmed patients, tumor diameters were <3 cm for the 27 (37.5%) patients and 3 to 5 cm for the 23 (31.9%) patients. Only 5 (6.9%) patients' conditions were too advanced to be actively treated. This study enrolled only 5.7% of the participants for US, which cover 64.7% to 71.3% of the HCC cases. Most (93%) of the detected cases were caught early enough to undergo effective treatment modalities. This HCC screening protocol should be feasible, economical, and effective.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1055-9965
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| pubmed:author |
pubmed-author:ChangKuo-ChinKC,
pubmed-author:ChangchienChi-SinCS,
pubmed-author:ChenChien-HungCH,
pubmed-author:ChenPao-FeiPF,
pubmed-author:ChenTony Hsiu-HsiTH,
pubmed-author:ChenYao-DerYD,
pubmed-author:HungChao-HungCH,
pubmed-author:KeeKwong-MingKM,
pubmed-author:LeeChuan-MoCM,
pubmed-author:LuSheng-NanSN,
pubmed-author:TsaiLin-SanLS,
pubmed-author:TsengPo-LinPL,
pubmed-author:TungHung-DaHD,
pubmed-author:WangJing-HoungJH
|
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1813-21
|
| pubmed:meshHeading |
pubmed-meshheading:18628436-Aged,
pubmed-meshheading:18628436-Carcinoma, Hepatocellular,
pubmed-meshheading:18628436-Community Health Services,
pubmed-meshheading:18628436-Female,
pubmed-meshheading:18628436-Humans,
pubmed-meshheading:18628436-Incidence,
pubmed-meshheading:18628436-Liver Neoplasms,
pubmed-meshheading:18628436-Male,
pubmed-meshheading:18628436-Mass Screening,
pubmed-meshheading:18628436-Middle Aged,
pubmed-meshheading:18628436-Prevalence,
pubmed-meshheading:18628436-Reproducibility of Results,
pubmed-meshheading:18628436-Retrospective Studies,
pubmed-meshheading:18628436-Risk Factors,
pubmed-meshheading:18628436-Sensitivity and Specificity,
pubmed-meshheading:18628436-Survival Rate,
pubmed-meshheading:18628436-Taiwan,
pubmed-meshheading:18628436-Thrombocytopenia
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Community-based mass ultrasonographic screening of hepatocellular carcinoma among thrombocytopenic adults.
|
| pubmed:affiliation |
Division of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC. juten@ms17.hinet.net
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
|