Source:http://linkedlifedata.com/resource/pubmed/id/18627369
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
Pt 5
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pubmed:dateCreated |
2008-10-8
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pubmed:abstractText |
Acute intermittent porphyria (AIP), an autosomal dominant disorder, is caused by partial deficiency of hydroxymethylbilane synthase (HMBS) affecting heme biosynthesis. Patients with AIP are characterized by recurrent abdominal pain, port-wine urine, and motor paresis. The disease can be provoked by changes in hormone levels, drugs and fasting. Molecular analysis for twenty-four unrelated Chinese AIP patients from Taiwan identified twenty-five HMBS mutations. There were 10 missense (40%), four nonsense (16%), five frame-shift (20%) and six splice site (24%) mutations. More than a half (15/25, 60%) of these mutations are predicted to produce a truncated protein. Four (c.33 + 5C>A, Arg26Cys, Arg26His, Arg325X) occurred more than once among the 24 families and one individual carried two mutations in the same allele, a missense (Gly221Asp) and a splice site mutation (c.652-1G>A). Of the 25 mutations, eleven were novel (Arg149Pro, Gly218Arg, Asn322X, Gly221Asp, Pro313X, c.88-4_-16delAAGTCTCTACCCG, c.1008_1019delCAGCCTGGCCAA, c.113delT, c.88-4_-16delAAGTCTCTACCCGinsCA, c.160delA, c.902_909delTCCCTGCC). No correlation between genetic defect and phenotype (both clinical and biochemical) was observed in this study.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-4800
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
683-6
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pubmed:meshHeading |
pubmed-meshheading:18627369-Adolescent,
pubmed-meshheading:18627369-Adult,
pubmed-meshheading:18627369-Asian Continental Ancestry Group,
pubmed-meshheading:18627369-Base Sequence,
pubmed-meshheading:18627369-DNA,
pubmed-meshheading:18627369-DNA Mutational Analysis,
pubmed-meshheading:18627369-Female,
pubmed-meshheading:18627369-Humans,
pubmed-meshheading:18627369-Hydroxymethylbilane Synthase,
pubmed-meshheading:18627369-Male,
pubmed-meshheading:18627369-Mutation,
pubmed-meshheading:18627369-Porphyria, Acute Intermittent,
pubmed-meshheading:18627369-Taiwan
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pubmed:year |
2008
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pubmed:articleTitle |
HMBS mutations in Chinese patients with acute intermittent porphyria.
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pubmed:affiliation |
Department of Neurology, National Taiwan University Hospital, National Taiwan University School of Medicine, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article
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