Linked Life Data

18627319

Source:http://linkedlifedata.com/resource/pubmed/id/18627319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-8-6
pubmed:abstractText
The Ras signaling pathway plays a predominant role during development and controls diverse biological process in all eukaryotic cells. It is a member of the large family of GTPases proteins that binds and hydrolyzes GTP. Ras is a lipid-anchored protein on the intracellular membrane compartments, and cycles between inactive GDP-bound and the signaling competent GTP-bound conformation. Studies have demonstrated Ras to be a central regulator in signal transduction pathways responding to diverse extracellular and intracellular stimuli. Much progress has been made towards delineating specific genes involved in the process of pluripotency and differentiation of stem cells. Here, we discuss recent aspects of Ras signaling pathways in mediating stem cell properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1431-6730
pubmed:author
pubmed:issnType
Print
pubmed:volume
389
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
791-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Prospective of Ras signaling in stem cells.
pubmed:affiliation
Department of Molecular Neurobiochemistry, Ruhr University Bochum, Bochum, Germany. koushik.chakrabarty@rub.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't