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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
2008-7-23
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pubmed:abstractText |
A fundamental question is what are the molecular determinants that lead to spontaneous preferential targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9-23 peptide sequence in type 1 diabetes. Anti-insulin B:9-23 T cell clones isolated from prediabetic NOD islets have a conserved Valpha-segment/Jalpha-segment, but no conservation of the alpha-chain N region and no conservation of the Vbeta-chain. Here, we show that the conserved T cell receptor alpha-chain generates insulin autoantibodies when transgenically or retrogenically introduced into mice without its corresponding Vbeta. We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-10470079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-10677521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-10756085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-11375327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-11488632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-12021111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-12639991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-12796471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-12925730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-14599847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-14614561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-14617043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-15220191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-15378058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-15889095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-15889096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-16275360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-16478822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-16670763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-16670772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-16804066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-17143333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-17406263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-17607359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-7520467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-7537670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-9122227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18626021-9218760
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10090-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18626021-Adoptive Transfer,
pubmed-meshheading:18626021-Animals,
pubmed-meshheading:18626021-Autoantibodies,
pubmed-meshheading:18626021-Base Sequence,
pubmed-meshheading:18626021-Clone Cells,
pubmed-meshheading:18626021-Conserved Sequence,
pubmed-meshheading:18626021-DNA Primers,
pubmed-meshheading:18626021-Female,
pubmed-meshheading:18626021-Genes, T-Cell Receptor alpha,
pubmed-meshheading:18626021-Genes, T-Cell Receptor beta,
pubmed-meshheading:18626021-Insulin,
pubmed-meshheading:18626021-Insulin Antibodies,
pubmed-meshheading:18626021-Interferon-gamma,
pubmed-meshheading:18626021-Islets of Langerhans,
pubmed-meshheading:18626021-Male,
pubmed-meshheading:18626021-Mice,
pubmed-meshheading:18626021-Mice, Inbred NOD,
pubmed-meshheading:18626021-Mice, Knockout,
pubmed-meshheading:18626021-Mice, SCID,
pubmed-meshheading:18626021-Mice, Transgenic,
pubmed-meshheading:18626021-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:18626021-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
Conserved T cell receptor alpha-chain induces insulin autoantibodies.
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pubmed:affiliation |
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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