18625557

Source:http://linkedlifedata.com/resource/pubmed/id/18625557

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0036751, umls-concept:C0456387, umls-concept:C1554184, umls-concept:C1579360, umls-concept:C1659436
pubmed:issue	15
pubmed:dateCreated	2008-7-29
pubmed:abstractText	The structure-activity relationship and the synthesis of novel N-benzyl-N-(pyrrolidin-3-yl)carboxamides as dual serotonin (5-HT) and noradrenaline (NA) monoamine reuptake inhibitors are described. Compounds such as 18 exhibited dual 5-HT and NA reuptake inhibition, good selectivity over dopamine (DA) reuptake inhibition and drug-like physicochemical properties consistent with CNS target space. Compound 18 was selected for further preclinical evaluation.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Amides, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2D6, http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Uptake Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1464-3405
pubmed:author	pubmed-author:FishPaul VPV, pubmed-author:FrayM JonathanMJ, pubmed-author:GurrellIanI, pubmed-author:MillsJames EJE, pubmed-author:StobieAlanA, pubmed-author:WakenhutFlorianF, pubmed-author:WhitlockGavin AGA
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4308-11
pubmed:meshHeading	pubmed-meshheading:18625557-Amides, pubmed-meshheading:18625557-Animals, pubmed-meshheading:18625557-Central Nervous System, pubmed-meshheading:18625557-Combinatorial Chemistry Techniques, pubmed-meshheading:18625557-Cytochrome P-450 CYP2D6, pubmed-meshheading:18625557-Dogs, pubmed-meshheading:18625557-Dopamine Uptake Inhibitors, pubmed-meshheading:18625557-Drug Design, pubmed-meshheading:18625557-Hepatocytes, pubmed-meshheading:18625557-Humans, pubmed-meshheading:18625557-Inhibitory Concentration 50, pubmed-meshheading:18625557-Microsomes, Liver, pubmed-meshheading:18625557-Molecular Conformation, pubmed-meshheading:18625557-Norepinephrine, pubmed-meshheading:18625557-Pyrrolidines, pubmed-meshheading:18625557-Serotonin, pubmed-meshheading:18625557-Serotonin Uptake Inhibitors, pubmed-meshheading:18625557-Structure-Activity Relationship
pubmed:year	2008
pubmed:articleTitle	N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
pubmed:affiliation	Department of Genitourinary Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. florian.wakenhut@pfizer.com
pubmed:publicationType	Journal Article