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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2008-7-29
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pubmed:abstractText |
Novel non-nucleoside inhibitors of HIV-RT that contain pyridazinone isosteres were prepared, and a series of triazolinones were found to be potent inhibitors of HIV replication. These compounds were active against several NNRTI-resistant virus strains. Pharmacokinetic studies indicated that inhibitor 7e has good bioavailability in rats. Several fragments of inhibitor 7c were prepared, and the binding of these compounds to HIV-RT was analyzed by surface plasmon resonance spectroscopy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AcharyaSahajaS,
pubmed-author:BriggsAndrewA,
pubmed-author:DunnJames PJP,
pubmed-author:ElworthyTodd RTR,
pubmed-author:FretlandJenniferJ,
pubmed-author:GiannettiAnthony MAM,
pubmed-author:HangJulie QJQ,
pubmed-author:HeilekGabrielleG,
pubmed-author:KaiserAnn CAC,
pubmed-author:KlumppKlausK,
pubmed-author:MartinMichaelM,
pubmed-author:SaitoY DavidYD,
pubmed-author:SmithMarkM,
pubmed-author:SuhJudy MJM,
pubmed-author:SwallowStevenS,
pubmed-author:SweeneyZachary KZK,
pubmed-author:WuJeffreyJ,
pubmed-author:YuLiL,
pubmed-author:ZhouAmy SAS
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4348-51
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pubmed:meshHeading |
pubmed-meshheading:18625554-Animals,
pubmed-meshheading:18625554-Anti-HIV Agents,
pubmed-meshheading:18625554-Combinatorial Chemistry Techniques,
pubmed-meshheading:18625554-Drug Resistance, Viral,
pubmed-meshheading:18625554-Molecular Structure,
pubmed-meshheading:18625554-Pyridazines,
pubmed-meshheading:18625554-Rats,
pubmed-meshheading:18625554-Reverse Transcriptase Inhibitors,
pubmed-meshheading:18625554-Structure-Activity Relationship,
pubmed-meshheading:18625554-Surface Plasmon Resonance,
pubmed-meshheading:18625554-Triazoles
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pubmed:year |
2008
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pubmed:articleTitle |
Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.
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pubmed:affiliation |
Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. zachary.sweeney@roche.com
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pubmed:publicationType |
Journal Article
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