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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2008-8-1
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pubmed:abstractText |
Comparative CO photolysis kinetics studies on wild-type and autoregulatory (AR) insert-deletion mutant of rat nNOS holoenzyme were conducted to directly investigate the role of the unique AR insert in the catalytically significant FMN-heme intraprotein electron transfer (IET). Although the amplitude of the IET kinetic traces was decreased two- to three-fold, the AR deletion did not change the rate constant for the calmodulin-controlled IET. This suggests that the rate-limiting conversion of the electron-accepting state to a new electron-donating (output) state does not involve interactions with the AR insert, but that AR may stabilize the output state once it is formed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-10600101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-11325964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-11329262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-11356143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-11463332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-11942792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-12456347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-14715665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-15208315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-15598508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-16249336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-16461329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-16536556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-16700546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-16782703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-17425311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-7528206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625229-9368047
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2768-72
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pubmed:dateRevised |
2011-6-17
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pubmed:meshHeading |
pubmed-meshheading:18625229-Animals,
pubmed-meshheading:18625229-Calmodulin,
pubmed-meshheading:18625229-Electron Transport,
pubmed-meshheading:18625229-Flavin Mononucleotide,
pubmed-meshheading:18625229-Heme,
pubmed-meshheading:18625229-Homeostasis,
pubmed-meshheading:18625229-INDEL Mutation,
pubmed-meshheading:18625229-Nitric Oxide Synthase,
pubmed-meshheading:18625229-Photolysis,
pubmed-meshheading:18625229-Protein Structure, Tertiary,
pubmed-meshheading:18625229-Rats
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pubmed:year |
2008
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pubmed:articleTitle |
Deletion of the autoregulatory insert modulates intraprotein electron transfer in rat neuronal nitric oxide synthase.
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pubmed:affiliation |
College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, United States. cfeng@salud.unm.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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