| pubmed-article:18622748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0286983 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C1705784 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0677626 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0812444 | lld:lifeskim |
| pubmed-article:18622748 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:18622748 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18622748 | pubmed:dateCreated | 2008-7-14 | lld:pubmed |
| pubmed-article:18622748 | pubmed:abstractText | We conducted a study concerning the suppressive mechanism of KAI1/CD82 on hepatoma cell metastasis. Hepatocyte growth factor (HGF) induces the migration of hepatoma cells through activation of cellular sphingosine kinase 1 (SphK1). Adenovirus-mediated gene transfer of KAI1 (Ad-KAI1) downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells. Overexpression of KAI1/CD82 significantly elevates Sprouty2 at the protein level. Ablation of Sprouty2 with RNA interference can block the KAI1/CD82-induced suppression of hepatoma cell migration and downregulation of SphK1 expression. It is demonstrated that KAI1/CD82 suppresses HGF-induced migration of hepatoma cells via upregulation of Sprouty2. | lld:pubmed |
| pubmed-article:18622748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18622748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18622748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18622748 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18622748 | pubmed:issn | 1006-9305 | lld:pubmed |
| pubmed-article:18622748 | pubmed:author | pubmed-author:WangHuaH | lld:pubmed |
| pubmed-article:18622748 | pubmed:author | pubmed-author:ZhangJingJ | lld:pubmed |
| pubmed-article:18622748 | pubmed:author | pubmed-author:WangLishengL | lld:pubmed |
| pubmed-article:18622748 | pubmed:author | pubmed-author:GuoXiaozhongX | lld:pubmed |
| pubmed-article:18622748 | pubmed:author | pubmed-author:LiQingfangQ | lld:pubmed |
| pubmed-article:18622748 | pubmed:author | pubmed-author:MuZhenbinZ | lld:pubmed |
| pubmed-article:18622748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18622748 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:18622748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18622748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18622748 | pubmed:pagination | 648-54 | lld:pubmed |
| pubmed-article:18622748 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:18622748 | pubmed:meshHeading | pubmed-meshheading:18622748... | lld:pubmed |
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| pubmed-article:18622748 | pubmed:meshHeading | pubmed-meshheading:18622748... | lld:pubmed |
| pubmed-article:18622748 | pubmed:meshHeading | pubmed-meshheading:18622748... | lld:pubmed |
| pubmed-article:18622748 | pubmed:meshHeading | pubmed-meshheading:18622748... | lld:pubmed |
| pubmed-article:18622748 | pubmed:meshHeading | pubmed-meshheading:18622748... | lld:pubmed |
| pubmed-article:18622748 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18622748 | pubmed:articleTitle | KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2. | lld:pubmed |
| pubmed-article:18622748 | pubmed:affiliation | State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. | lld:pubmed |
| pubmed-article:18622748 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18622748 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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