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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-14
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pubmed:abstractText |
We conducted a study concerning the suppressive mechanism of KAI1/CD82 on hepatoma cell metastasis. Hepatocyte growth factor (HGF) induces the migration of hepatoma cells through activation of cellular sphingosine kinase 1 (SphK1). Adenovirus-mediated gene transfer of KAI1 (Ad-KAI1) downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells. Overexpression of KAI1/CD82 significantly elevates Sprouty2 at the protein level. Ablation of Sprouty2 with RNA interference can block the KAI1/CD82-induced suppression of hepatoma cell migration and downregulation of SphK1 expression. It is demonstrated that KAI1/CD82 suppresses HGF-induced migration of hepatoma cells via upregulation of Sprouty2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1006-9305
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
648-54
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18622748-Adenoviridae,
pubmed-meshheading:18622748-Antigens, CD82,
pubmed-meshheading:18622748-Carcinoma, Hepatocellular,
pubmed-meshheading:18622748-Cell Line, Tumor,
pubmed-meshheading:18622748-Cell Movement,
pubmed-meshheading:18622748-Enzyme Activation,
pubmed-meshheading:18622748-Hepatocyte Growth Factor,
pubmed-meshheading:18622748-Humans,
pubmed-meshheading:18622748-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18622748-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:18622748-RNA, Small Interfering,
pubmed-meshheading:18622748-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2.
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|
pubmed:affiliation |
State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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