Linked Life Data

18622263

Source:http://linkedlifedata.com/resource/pubmed/id/18622263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-7-14
pubmed:abstractText
Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the metabolism of some clinical drugs, carcinogens, and steroid hormones. The molecular mechanisms of the inducible expression of UGT2B7 in response to xenobiotics have not been fully clarified. We sought to investigate whether the UGT2B7 is under the control of NF-E2 p45-related factor 2 (Nrf2), a key transcriptional factor regulating the expression of cytoprotective enzymes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1744-6872
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
709-20
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18622263-5' Flanking Region, pubmed-meshheading:18622263-Alleles, pubmed-meshheading:18622263-Antioxidants, pubmed-meshheading:18622263-Base Sequence, pubmed-meshheading:18622263-Cell Line, Tumor, pubmed-meshheading:18622263-Electrophoretic Mobility Shift Assay, pubmed-meshheading:18622263-Gene Expression Regulation, pubmed-meshheading:18622263-Glucuronosyltransferase, pubmed-meshheading:18622263-Humans, pubmed-meshheading:18622263-Luciferases, pubmed-meshheading:18622263-Molecular Sequence Data, pubmed-meshheading:18622263-NF-E2 Transcription Factor, p45 Subunit, pubmed-meshheading:18622263-Polymorphism, Genetic, pubmed-meshheading:18622263-Polymorphism, Single Nucleotide, pubmed-meshheading:18622263-Protein Binding, pubmed-meshheading:18622263-RNA, Small Interfering, pubmed-meshheading:18622263-Response Elements, pubmed-meshheading:18622263-Sequence Analysis, DNA, pubmed-meshheading:18622263-Thiocyanates, pubmed-meshheading:18622263-Transcription, Genetic, pubmed-meshheading:18622263-Transcriptional Activation
pubmed:year
2008
pubmed:articleTitle
Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation.
pubmed:affiliation
Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma-Machi, Kanazawa, Japan.
pubmed:publicationType
Journal Article