18622261

Source:http://linkedlifedata.com/resource/pubmed/id/18622261

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017337, umls-concept:C0205419, umls-concept:C0278372, umls-concept:C0752046, umls-concept:C1880355
pubmed:issue	8
pubmed:dateCreated	2008-7-14
pubmed:abstractText	UDP-glucuronosyltransferase 2B7 (UGT2B7) plays a central role in the liver-mediated biotransformation of endogenous and exogenous compounds. The genetic basis of interindividual variability in UGT2B7 function is unknown. This study aimed to discover novel gene variants of functional significance.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/U01 GM 61374, http://linkedlifedata.com/resource/pubmed/grant/U01 GM 61393, http://linkedlifedata.com/resource/pubmed/grant/U01 GM061393-01, http://linkedlifedata.com/resource/pubmed/grant/U01 GM061393-02, http://linkedlifedata.com/resource/pubmed/grant/U01 GM061393-03, http://linkedlifedata.com/resource/pubmed/grant/U01 GM061393-04, http://linkedlifedata.com/resource/pubmed/grant/U01 GM061393-05, http://linkedlifedata.com/resource/pubmed/grant/U01 GM061393-06
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101231005
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Epirubicin, http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase, http://linkedlifedata.com/resource/pubmed/chemical/Morphine Derivatives, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/UDP-glucuronosyltransferase, UGT2B7, http://linkedlifedata.com/resource/pubmed/chemical/morphine-3-glucuronide, http://linkedlifedata.com/resource/pubmed/chemical/morphine-6-glucuronide
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1744-6872
pubmed:author	pubmed-author:ByersM EME, pubmed-author:ChenPeixianP, pubmed-author:DasSomaS, pubmed-author:FackenthalDonnaD, pubmed-author:InnocentiFedericoF, pubmed-author:LiuWanqingW, pubmed-author:MirkovSnezanaS, pubmed-author:RamírezJacquelineJ, pubmed-author:RatainMark JMJ, pubmed-author:WuXiaolinX, pubmed-author:YowPP, pubmed-author:ZhangWeiW
pubmed:issnType	Print
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	683-97
pubmed:dateRevised	2011-6-14
pubmed:meshHeading	pubmed-meshheading:18622261-Alternative Splicing, pubmed-meshheading:18622261-Base Sequence, pubmed-meshheading:18622261-Epirubicin, pubmed-meshheading:18622261-Exons, pubmed-meshheading:18622261-Gene Expression Regulation, Enzymologic, pubmed-meshheading:18622261-Genetic Variation, pubmed-meshheading:18622261-Glucuronosyltransferase, pubmed-meshheading:18622261-Haplotypes, pubmed-meshheading:18622261-Humans, pubmed-meshheading:18622261-Liver, pubmed-meshheading:18622261-Molecular Sequence Data, pubmed-meshheading:18622261-Morphine Derivatives, pubmed-meshheading:18622261-Phenotype, pubmed-meshheading:18622261-Polymorphism, Single Nucleotide, pubmed-meshheading:18622261-RNA, Messenger, pubmed-meshheading:18622261-Regression Analysis, pubmed-meshheading:18622261-Sequence Analysis, DNA
pubmed:year	2008
pubmed:articleTitle	Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene.
pubmed:affiliation	Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. finnocen@medicine.bsd.uchicago.edu
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't

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