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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-7-14
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pubmed:abstractText |
Epithelial-to-mesenchymal transition contributes to renal fibrogenesis, which is regulated by profibrogenic and antifibrogenic mediators. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors can prevent epithelial-to-mesenchymal transition in some models. Therefore, we tested the hypothesis that epithelial-to-mesenchymal transition participates in renal injury in porcine atherosclerotic renovascular disease and can be attenuated by simvastatin.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0263-6352
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1651-60
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pubmed:meshHeading |
pubmed-meshheading:18622245-Animals,
pubmed-meshheading:18622245-Atherosclerosis,
pubmed-meshheading:18622245-Blood Pressure,
pubmed-meshheading:18622245-Disease Models, Animal,
pubmed-meshheading:18622245-Epithelial Cells,
pubmed-meshheading:18622245-Fibrosis,
pubmed-meshheading:18622245-Glomerular Filtration Rate,
pubmed-meshheading:18622245-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:18622245-Hypertension, Renal,
pubmed-meshheading:18622245-Mesenchymal Stem Cells,
pubmed-meshheading:18622245-Renal Artery Obstruction,
pubmed-meshheading:18622245-Renal Circulation,
pubmed-meshheading:18622245-Simvastatin,
pubmed-meshheading:18622245-Sus scrofa
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pubmed:year |
2008
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pubmed:articleTitle |
Simvastatin abates development of renal fibrosis in experimental renovascular disease.
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pubmed:affiliation |
Department of Internal Medicine (Divisions of Nephrology and Hypertension), Mayo Clinic, Rochester, Minnesota 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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