Source:http://linkedlifedata.com/resource/pubmed/id/18621447
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-2-17
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| pubmed:abstractText |
The association of R219K and V825I polymorphisms of ABCA1 gene with cerebral infarction has been rarely reported. Here we wish to address this issue. A total of 476 subjects from Chinese Han ethnic population were investigated, including 152 control individuals and 324 patients with cerebral infarction. Genotyping of R219K and V825I were performed by PCR-RFLP analysis. Data were analyzed using a statistical package. The R219K genotype frequency distributions were significantly different between patients with atherothrombotic cerebral infarction (ACI) and control individuals, with fewer KK genotypes and more RR genotypes in ACI patients (chi(2)=9.89, P<0.01). The K allele is less frequent among ACI patients than in controls (chi(2)=9.16, P<0.005). A significant association of KK with decreased ACI risk was exhibited, especially in male patients, aged patients and individuals with hypertension. These results indicate that the K allele of R219K polymorphism is an independent protective factor against ACI. In addition, though there is no association of V825I with ACI, this polymorphism may have certain synergistic effect with hypertension in susceptibility to ACI.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1558-1497
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2008 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
31
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
647-53
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| pubmed:meshHeading |
pubmed-meshheading:18621447-ATP-Binding Cassette Transporters,
pubmed-meshheading:18621447-Adult,
pubmed-meshheading:18621447-Age Distribution,
pubmed-meshheading:18621447-Aged,
pubmed-meshheading:18621447-Aged, 80 and over,
pubmed-meshheading:18621447-Asian Continental Ancestry Group,
pubmed-meshheading:18621447-Cerebral Infarction,
pubmed-meshheading:18621447-China,
pubmed-meshheading:18621447-DNA Mutational Analysis,
pubmed-meshheading:18621447-Female,
pubmed-meshheading:18621447-Gene Frequency,
pubmed-meshheading:18621447-Genetic Markers,
pubmed-meshheading:18621447-Genetic Predisposition to Disease,
pubmed-meshheading:18621447-Genetic Testing,
pubmed-meshheading:18621447-Genotype,
pubmed-meshheading:18621447-Humans,
pubmed-meshheading:18621447-Hypertension,
pubmed-meshheading:18621447-Intracranial Arteriosclerosis,
pubmed-meshheading:18621447-Male,
pubmed-meshheading:18621447-Middle Aged,
pubmed-meshheading:18621447-Polymorphism, Genetic,
pubmed-meshheading:18621447-Sex Distribution
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| pubmed:year |
2010
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| pubmed:articleTitle |
The R219K polymorphism in the ATP-binding cassette transporter 1 gene has a protective effect on atherothrombotic cerebral infarction in Chinese Han ethnic population.
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| pubmed:affiliation |
Department of Neurology and Institute of Neurology, First Affiliated Hospital, Center of Neuroscience, Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|