Linked Life Data

18620054

Source:http://linkedlifedata.com/resource/pubmed/id/18620054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-8-25
pubmed:abstractText
The functioning of many biochemical networks is often robust-remarkably stable under changes in external conditions and internal reaction parameters. Much recent work on robustness and evolvability has focused on the structure of neutral spaces, in which system behavior remains invariant to mutations. Recently we have shown that the collective behavior of multiparameter models is most often sloppy: insensitive to changes except along a few 'stiff' combinations of parameters, with an enormous sloppy neutral subspace. Robustness is often assumed to be an emergent evolved property, but the sloppiness natural to biochemical networks offers an alternative nonadaptive explanation. Conversely, ideas developed to study evolvability in robust systems can be usefully extended to characterize sloppy systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0958-1669
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-95
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Sloppiness, robustness, and evolvability in systems biology.
pubmed:affiliation
Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, NY, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review