18619367

Source:http://linkedlifedata.com/resource/pubmed/id/18619367

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0024266, umls-concept:C0936072, umls-concept:C1279941, umls-concept:C1520023
pubmed:issue	3
pubmed:dateCreated	2008-7-14
pubmed:abstractText	Amantadine hydrochloride inhibits the CA1371, UBC, and WE strains of LCM in both BHK21/13S and L-929 cells. The compound has no direct inactivating effect on virus infectivity nor does it affect the adsorption of virus to cells. By observing the susceptibility of cell-adsorbed virus to neutralizing antibody, amantadine was shown to delay virion penetration. Furthermore, addition of the drug at any time during ongoing viral replication, with all cells scoring as infective centers, inhibits virus synthesis and release.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0110674
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Sep
pubmed:issn	0042-6822
pubmed:author	pubmed-author:KowalskiJ BJB, pubmed-author:O'ConnellC MCM, pubmed-author:PfauC JCJ, pubmed-author:TrowbridgeR SRS, pubmed-author:WelshR MRM
pubmed:issnType	Print
pubmed:volume	45
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	679-86
pubmed:year	1971
pubmed:articleTitle	Amantadine hydrochloride inhibition of early and late stages of lymphocytic choriomeningitis virus-cell interactions.
pubmed:affiliation	Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01002, USA.
pubmed:publicationType	Journal Article