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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-7-11
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pubmed:abstractText |
CX3CR1, the receptor of CX3CL1/fractalkine, is involved in regulation of inflammatory response and the CX3CR1-I249-M280 naturally occurring mutants are associated with altered binding to the ligand. Our aim was to evaluate the frequency of CX3CR1 V249I and T280M polymorphisms and NOD2/CARD15 mutations in Crohn's disease patients and to search for a relationship with phenotype.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0954-691X
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pubmed:author |
pubmed-author:AmezianeNejmaN,
pubmed-author:CoffinBenoitB,
pubmed-author:DeybachJean-CharlesJC,
pubmed-author:FarmachidiJean-PierreJP,
pubmed-author:HarnoisFlorenceF,
pubmed-author:JianRaymondR,
pubmed-author:JouetPaulineP,
pubmed-author:LamorilJérômeJ,
pubmed-author:SabateJean-MarcJM,
pubmed-author:SobhaniIradjI,
pubmed-author:SouléJean-ClaudeJC,
pubmed-author:de ProstDominiqueD
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
748-55
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pubmed:dateRevised |
2009-10-16
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pubmed:meshHeading |
pubmed-meshheading:18617779-Adult,
pubmed-meshheading:18617779-Age of Onset,
pubmed-meshheading:18617779-Crohn Disease,
pubmed-meshheading:18617779-Female,
pubmed-meshheading:18617779-Genetic Predisposition to Disease,
pubmed-meshheading:18617779-Genotype,
pubmed-meshheading:18617779-Humans,
pubmed-meshheading:18617779-Intestinal Obstruction,
pubmed-meshheading:18617779-Male,
pubmed-meshheading:18617779-Middle Aged,
pubmed-meshheading:18617779-Mutation,
pubmed-meshheading:18617779-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:18617779-Phenotype,
pubmed-meshheading:18617779-Polymorphism, Genetic,
pubmed-meshheading:18617779-Receptors, Chemokine,
pubmed-meshheading:18617779-Retrospective Studies,
pubmed-meshheading:18617779-Risk Factors,
pubmed-meshheading:18617779-Smoking
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pubmed:year |
2008
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pubmed:articleTitle |
The V249I polymorphism of the CX3CR1 gene is associated with fibrostenotic disease behavior in patients with Crohn's disease.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, AP-HP, Louis Mourier Hospital, Colombes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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