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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-8-26
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pubmed:abstractText |
Postsynaptic density-95 inhibitors reduce ischemic brain damage without inhibiting excitatory neurotransmission, circumventing the negative consequences of glutamatergic inhibition. However, their efficacy in permanent ischemia and in providing permanent neuroprotection and neurobehavioral improvement in a practical therapeutic window is unproven. These were tested here under conditions that included fever, which is a common occurrence in clinical stroke.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4628
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pubmed:author |
pubmed-author:AartsMichelleM,
pubmed-author:BernardPaul BPB,
pubmed-author:DoucetteTracy ATA,
pubmed-author:FangYuanY,
pubmed-author:ForderJoan PJP,
pubmed-author:LauAnthonyA,
pubmed-author:LiuYitaoY,
pubmed-author:RyanCatherine LCL,
pubmed-author:SalterMichael WMW,
pubmed-author:SunHong-ShuoHS,
pubmed-author:TaskerR AndrewRA,
pubmed-author:TevesLucyL,
pubmed-author:TymianskiMichaelM,
pubmed-author:WangYu TianYT
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2544-53
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pubmed:meshHeading |
pubmed-meshheading:18617669-Animals,
pubmed-meshheading:18617669-Body Temperature,
pubmed-meshheading:18617669-Brain,
pubmed-meshheading:18617669-Brain Infarction,
pubmed-meshheading:18617669-Brain Ischemia,
pubmed-meshheading:18617669-Disease Models, Animal,
pubmed-meshheading:18617669-Female,
pubmed-meshheading:18617669-Fever,
pubmed-meshheading:18617669-Infarction, Middle Cerebral Artery,
pubmed-meshheading:18617669-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18617669-Ischemic Attack, Transient,
pubmed-meshheading:18617669-Male,
pubmed-meshheading:18617669-Membrane Proteins,
pubmed-meshheading:18617669-Nerve Degeneration,
pubmed-meshheading:18617669-Peptides,
pubmed-meshheading:18617669-Rats,
pubmed-meshheading:18617669-Rats, Sprague-Dawley,
pubmed-meshheading:18617669-Recombinant Fusion Proteins,
pubmed-meshheading:18617669-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
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pubmed:affiliation |
Toronto Western Hospital Research Institute, Suite 4W-435, 399 Bathurst Street, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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