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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2008-9-8
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pubmed:abstractText |
Large-scale genetic association studies are carried out with the hope of discovering single nucleotide polymorphisms involved in the etiology of complex diseases. There are several existing methods in the literature for performing this kind of analysis for case-control studies, but less work has been done for prospective cohort studies. We present a Bayesian method for linking markers to censored survival outcome by clustering haplotypes using gene trees. Coalescent-based approaches are promising for LD mapping, as the coalescent offers a good approximation to the evolutionary history of mutations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-11254454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-12686700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-14576852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-15047504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-15452305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-15452306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-15857428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-15946327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-16708052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-16857572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-17616979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18617538-17947444
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1367-4811
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2030-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18617538-ATP-Binding Cassette Transporters,
pubmed-meshheading:18617538-Bayes Theorem,
pubmed-meshheading:18617538-Computer Simulation,
pubmed-meshheading:18617538-Epilepsy,
pubmed-meshheading:18617538-Genetic Predisposition to Disease,
pubmed-meshheading:18617538-Genome, Human,
pubmed-meshheading:18617538-Haplotypes,
pubmed-meshheading:18617538-Humans,
pubmed-meshheading:18617538-Linkage Disequilibrium,
pubmed-meshheading:18617538-Polymorphism, Single Nucleotide,
pubmed-meshheading:18617538-Survival Analysis
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pubmed:year |
2008
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pubmed:articleTitle |
Bayesian survival analysis in genetic association studies.
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pubmed:affiliation |
Department of Epidemiology and Public Health, Imperial College, London, UK. ioanna.tachmazidou@imperial.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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