Linked Life Data

18617334

Source:http://linkedlifedata.com/resource/pubmed/id/18617334

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-11-5
pubmed:abstractText
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0344-0338
pubmed:author
pubmed:issnType
Print
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
793-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Loss of heterozygosity of the APC gene in oral squamous cell carcinoma.
pubmed:affiliation
Department of Pathology, Health Science Center, Federal University of Santa Catarina, CEP 88040-370, Florianópolis, SC, Brazil. riet@ccs.ufsc.br
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't