Linked Life Data

18617041

Source:http://linkedlifedata.com/resource/pubmed/id/18617041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-7-11
pubmed:abstractText
Tissue development in multicellular animals relies on the ability of cells to synthesize an extracellular matrix (ECM) containing spatially organized collagen fibrils, whose length greatly exceeds that of individual cells. The importance of the correct regulation of fibril deposition is exemplified in diseases such as osteogenesis imperfecta (caused by mutations in collagen genes), fibrosis (caused by ectopic accumulation of collagen), and cardiovascular disease (which involves cells and macromolecules binding to collagen in the vessel wall). Much is known about the molecular biology of collagens but less is known about collagen fibril structure and how the fibrils are formed (fibrillogenesis). This is explained in part by the fact that the fibrils are noncrystalline, extensively cross-linked, and very large, which makes them refractory to study by conventional biochemical and high-resolution structure-determination techniques. Electron microscopy has become established as the method of choice for studying collagen fibril structure and assembly. This article describes the electron microscopic methods most often used in studying collagen fibril assembly and structure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0091-679X
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-45
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction.
pubmed:affiliation
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't