Linked Life Data

18616612

Source:http://linkedlifedata.com/resource/pubmed/id/18616612

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-12-16
pubmed:abstractText
SK3 K(+) channels influence neuronal excitability and are present in 5-hydroxytryptamine (5-HT) and dopamine (DA) nuclei in the brain stem. We therefore hypothesized that SK3 channels affect 5-HT and DA neurotransmission and associated behaviors. To explore this, we used doxycycline-induced conditional SK3-deficient (T/T) mice. In microdialysis, T/T mice had elevated baseline levels of striatal extracellular DA and the metabolites dihydroxyphenylacetic acid and homovanillic acid. While baseline hippocampal extracellular 5-HT was unchanged in T/T mice, the 5-HT response to the 5-HT transporter inhibitor citalopram was enhanced. Furthermore, baseline levels of the 5-HT metabolite 5-hydroxyindoleacetic acid were elevated in T/T mice. T/T mice performed equally to wild type (WT) in most sensory and motor tests, indicating that SK3 deficiency does not lead to gross impairments. In the forced swim and tail suspension tests, the T/T mice displayed reduced immobility compared with WT, indicative of an antidepressant-like phenotype. Female T/T mice were more anxious in the zero maze. In contrast, anxiety-like behaviors in the open-field and four-plate tests were unchanged in T/T mice of both sexes. Home cage diurnal activity was also unchanged in T/T mice. However, SK3 deficiency had a complex effect on activity responses to novelty: T/T mice showed decreased, increased or unchanged activity responses to novelty, depending on sex and context. In summary, we report that SK3 deficiency leads to enhanced DA and 5-HT neurotransmission accompanied by distinct alterations in emotional behaviors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1601-183X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
836-48
pubmed:meshHeading
pubmed-meshheading:18616612-Animals, pubmed-meshheading:18616612-Anti-Bacterial Agents, pubmed-meshheading:18616612-Anxiety Disorders, pubmed-meshheading:18616612-Behavior, Animal, pubmed-meshheading:18616612-Brain, pubmed-meshheading:18616612-Citalopram, pubmed-meshheading:18616612-Delirium, Dementia, Amnestic, Cognitive Disorders, pubmed-meshheading:18616612-Dopamine, pubmed-meshheading:18616612-Doxycycline, pubmed-meshheading:18616612-Emotions, pubmed-meshheading:18616612-Exploratory Behavior, pubmed-meshheading:18616612-Female, pubmed-meshheading:18616612-Hydroxyindoleacetic Acid, pubmed-meshheading:18616612-Male, pubmed-meshheading:18616612-Mice, pubmed-meshheading:18616612-Mice, Inbred C57BL, pubmed-meshheading:18616612-Mice, Knockout, pubmed-meshheading:18616612-Serotonin, pubmed-meshheading:18616612-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:18616612-Serotonin Uptake Inhibitors, pubmed-meshheading:18616612-Sex Characteristics, pubmed-meshheading:18616612-Small-Conductance Calcium-Activated Potassium Channels, pubmed-meshheading:18616612-Synaptic Transmission
pubmed:year
2008
pubmed:articleTitle
SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors.
pubmed:affiliation
Department of In Vivo Pharmacology, Neurosearch A/S, Ballerup, Denmark. jacobpade@hotmail.com
pubmed:publicationType
Journal Article