| pubmed-article:18616564 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C1150579 | lld:lifeskim |
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| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C1150481 | lld:lifeskim |
| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C1705791 | lld:lifeskim |
| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:18616564 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18616564 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18616564 | pubmed:dateCreated | 2008-7-30 | lld:pubmed |
| pubmed-article:18616564 | pubmed:abstractText | The function of the isolectin B4 (IB4+)-binding and GDNF-dependent Ret (Ret+)-expressing non-peptidergic subpopulation of nociceptors remain poorly understood. We demonstrate that acute administration of GDNF sensitizes nociceptors and produces mechanical hyperalgesia in the rat. Intrathecal IB4-saporin, a selective toxin for IB4+/Ret+-nociceptors, attenuates GDNF but not NGF hyperalgesia. Conversely, intrathecal antisense to Trk A attenuated NGF but not GDNF hyperalgesia. Intrathecal administration of antisense oligodeoxynucleotides targeting mRNA for versican, the molecule that renders the Ret-expressing nociceptors IB4-positive (+), also attenuated GDNF but not NGF hyperalgesia, as did ADAMTS-4, a matrix metalloprotease known to degrade versican. Finally, inhibitors for all five signaling pathways known to be activated by GDNF at GFRa1/Ret: PLCc, CDK5, PI3K,MAPK/ERK and Src family kinases, attenuated GDNF hyperalgesia. Our results demonstrate a role of the non-peptidergic nociceptors in pain produced by the neurotrophin GDNF and suggest that the IB4-binding protein versican functions in the expression of this phenotype. | lld:pubmed |
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| pubmed-article:18616564 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18616564 | pubmed:citationSubset | IM | lld:pubmed |
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