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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-9-29
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pubmed:abstractText |
Homoharringtonine (HHT) was efficient in therapying patients with acute myeloid leukemia (AML) in China, but little is known about the mechanism of its action. As the abnormal activation of JAK2 associated pathway is important to AML, we try to explore the effect of HHT on JAK2-STAT pathway in AML cells, thus supplying theoretical basis for wider use of HHT.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bcr-Abl tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Harringtonines,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein v-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyano-(3,4-dihydroxy)-N-benzyl...,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/homoharringtonine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1600-0609
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-66
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18616510-Amino Acid Substitution,
pubmed-meshheading:18616510-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:18616510-Apoptosis,
pubmed-meshheading:18616510-Cell Survival,
pubmed-meshheading:18616510-Dose-Response Relationship, Drug,
pubmed-meshheading:18616510-Drug Screening Assays, Antitumor,
pubmed-meshheading:18616510-Fusion Proteins, bcr-abl,
pubmed-meshheading:18616510-HL-60 Cells,
pubmed-meshheading:18616510-Harringtonines,
pubmed-meshheading:18616510-Humans,
pubmed-meshheading:18616510-Janus Kinase 2,
pubmed-meshheading:18616510-K562 Cells,
pubmed-meshheading:18616510-Leukemia, Myeloid, Acute,
pubmed-meshheading:18616510-Mutation, Missense,
pubmed-meshheading:18616510-Oncogene Protein v-akt,
pubmed-meshheading:18616510-Phosphorylation,
pubmed-meshheading:18616510-Protein Kinase Inhibitors,
pubmed-meshheading:18616510-Protein-Tyrosine Kinases,
pubmed-meshheading:18616510-STAT5 Transcription Factor,
pubmed-meshheading:18616510-Signal Transduction,
pubmed-meshheading:18616510-Tyrphostins,
pubmed-meshheading:18616510-bcl-X Protein
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pubmed:year |
2008
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pubmed:articleTitle |
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.
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pubmed:affiliation |
Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China. hongyantong@yahoo.com.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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