| pubmed-article:18614013 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18614013 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:18614013 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18614013 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:18614013 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:18614013 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18614013 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18614013 | pubmed:dateCreated | 2008-7-10 | lld:pubmed |
| pubmed-article:18614013 | pubmed:abstractText | Transcriptional activation of the IFN-beta gene by virus infection requires the cooperative assembly of an enhanceosome. We report that the stochastic and monoallelic expression of the IFN-beta gene depends on interchromosomal associations with three identified distinct genetic loci that could mediate binding of the limiting transcription factor NF-kappaB to the IFN-beta enhancer, thus triggering enhanceosome assembly and activation of transcription from this allele. The probability of a cell to express IFN-beta is dramatically increased when the cell is transfected with any of these loci. The secreted IFN-beta protein induces high-level expression of the enhanceosome factor IRF-7, which in turn promotes enhanceosome assembly and IFN-beta transcription from the remaining alleles and in other initially nonexpressing cells. Thus, the IFN-beta enhancer functions in a nonlinear fashion by working as a signal amplifier. | lld:pubmed |
| pubmed-article:18614013 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614013 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18614013 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614013 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18614013 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18614013 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18614013 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:18614013 | pubmed:author | pubmed-author:ThanosDimitri... | lld:pubmed |
| pubmed-article:18614013 | pubmed:author | pubmed-author:ApostolouEffi... | lld:pubmed |
| pubmed-article:18614013 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18614013 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:18614013 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:18614013 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18614013 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18614013 | pubmed:pagination | 85-96 | lld:pubmed |
| pubmed-article:18614013 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:18614013 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18614013 | pubmed:articleTitle | Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression. | lld:pubmed |
| pubmed-article:18614013 | pubmed:affiliation | Institute of Molecular Biology, Genetics and Biotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Efesiou Street, Athens 11527, Greece. | lld:pubmed |
| pubmed-article:18614013 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18614013 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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