Linked Life Data

18611425

Source:http://linkedlifedata.com/resource/pubmed/id/18611425

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2008-8-29
pubmed:abstractText
We recently reported that para-nonylphenol, an environmental chemical, induced hydroxyl radical (*OH) formation in rat striatum. In this study we examined the antioxidant effects of angiotensin-converting enzyme inhibitors (captopril or enalaprilat) on para-nonylphenol (nonylphenol) and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum, using a microdialysis technique. para-Nonylphenol clearly enhanced *OH formation and DA efflux induced by MPP(+). When captopril or enalaprilat was infused in nonylphenol and MPP(+)-treated rats, DA efflux and OH formation significantly decreased, as compared with that in the nonylphenol and MPP(+)-treated control. We compared the ability of non-SH-containing enalaprilat with a SH-containing captopril to scavenge OH and DA efflux. Both inhibitors were able to scavenge *OH and DA efflux induced by para-nonylphenol and MPP(+). The results suggest that angiotensin-converting enzyme inhibitors may protect against nonylphenol and MPP(+)-induced *OH formation via suppressing DA efflux in the rat striatum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
250
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Protective effect of captopril and enalaprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced *OH generation and dopamine efflux in rat striatum.
pubmed:affiliation
Department of Analytical Chemistry, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima 963-8611, Japan. t-obata@pha.ohu-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't