Linked Life Data

18608176

Source:http://linkedlifedata.com/resource/pubmed/id/18608176

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-10-15
pubmed:abstractText
Alopecia areata (AA) is a chronic inflammatory disease with evidence of T-cell involvement that causes hair follicle "immune privilege collapse". Nitric monoxide was shown to contribute in the pathogenesis of AA. We are investigating evidence for the association of eNOS gene polymorphism with AA. Genomic DNA was extracted from 176 subjects, 87 Kuwaiti AA patients and 89 matched (for ethnicity, gender and age) healthy controls. A variable number tandem repeat (VNTR) located in intron-4 of the eNOS gene consisting of either four or five (27-base pair) repeats was analyzed by polymerase chain reaction and electrophoresis fragment analysis using ABI 3100 genetic analyzer. Haploview and GenePOP software were used for data analysis. A significant association was found between the intron-4 27 bp-VNTR and AA, where 4b was identified as the risk allele had (chi(2) = 4.42, p = 0.035, OR = 2.03). Genotype (4b/4b) showed a significant association with susceptibility to AA and have a frequency of 22% higher in AA patients than in healthy controls (71 vs 49%) and a chi(2) = 6.39, (p = 0.011, OR = 2.63). We report a significant association of a polymorphism within the eNOS gene and susceptibility to AA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1607-842X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Susceptible and protective endothelial nitric oxide synthase gene polymorphism in alopecia areata in the Kuwaiti population.
pubmed:affiliation
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't