Linked Life Data

18607712

Source:http://linkedlifedata.com/resource/pubmed/id/18607712

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-9-22
pubmed:abstractText
Nicotine exerts beneficial effects on various neurological and psychiatric pathologies, yet its effects on cognitive performance remain unclear. Mice lacking the beta2 subunit of the nicotinic receptor (beta2-/-) show characteristic deficits in executive functions and are suggested as reliable animal models for some specific endophenotypes of human pathologies, notably ADHD. We use beta2-/- and their controls to investigate the consequences of chronic nicotine exposure on cognitive behaviour. We show that in control mice, this treatment elicits somewhat slight effects, particularly affecting nocturnal activity and self-grooming. By contrast, in beta2-/- mice, chronic nicotine treatment had restorative effects on exploratory behaviour in the open-field and affected rearing, but did not modify motor functions. We confirmed that beta2-/- mice exhibit impaired exploratory and social behaviour, and further demonstrated their nocturnal hyperactivity. These data support the proposal that beta2-/- mice represent a relevant model for cognitive disorders in humans and that nicotine administered chronically at low dose may relieve some of these.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1573-3297
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-14
pubmed:dateRevised
2010-1-13
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Chronic nicotine exposure has dissociable behavioural effects on control and beta2-/- mice.
pubmed:affiliation
Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Department of Neuroscience and CNRS URA2182, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't