Linked Life Data

1860716

Source:http://linkedlifedata.com/resource/pubmed/id/1860716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-9-3
pubmed:abstractText
This study was performed to determine if an alteration in vascular polyamine contents is associated with the development of deoxycorticosterone acetate-salt hypertension. The effects of chronic administration of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase and thus polyamine biosynthesis, on vascular polyamine contents, structure, and function as well as the development of hypertension was studied. Control and deoxycorticosterone acetate-salt rats received either tap water or a drinking solution containing alpha-difluoromethylornithine for 6 weeks, during which period systolic blood pressures were recorded. Vascular reactivity studies were performed on rings of aorta and tail artery. Medial thickness, vessel weight, and vascular polyamine contents were also assessed in these arteries. alpha-difluoromethylornithine treatment had no significant effect on either systolic blood pressure or vascular structure, function, and polyamine contents of control animals. The elevation in blood pressure and the increase in medial thickness, ring weight, and vascular polyamine contents as well as altered vascular reactivity observed in deoxycorticosterone acetate-salt rats was significantly attenuated by alpha-difluoromethylornithine treatment. These results are the first to demonstrate that vascular polyamine contents are elevated in the deoxycorticosterone acetate-salt rat and that chronic alpha-difluoromethylornithine treatment prevents the rise in vascular polyamines as well as the elevation in blood pressure and attendant changes in the vasculature. Thus, the increase in vascular polyamines may comprise a critical link between the initiating stimuli and the alterations in vascular structure and function implicated in the pathogenesis of deoxycorticosterone acetate-salt hypertension.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0194-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1860716-Acetylcholine, pubmed-meshheading:1860716-Animals, pubmed-meshheading:1860716-Aorta, pubmed-meshheading:1860716-Arteries, pubmed-meshheading:1860716-Blood Pressure, pubmed-meshheading:1860716-Body Weight, pubmed-meshheading:1860716-Desoxycorticosterone, pubmed-meshheading:1860716-Dose-Response Relationship, Drug, pubmed-meshheading:1860716-Eflornithine, pubmed-meshheading:1860716-Heart, pubmed-meshheading:1860716-Heart Rate, pubmed-meshheading:1860716-Hypertension, pubmed-meshheading:1860716-Male, pubmed-meshheading:1860716-Muscle, Smooth, Vascular, pubmed-meshheading:1860716-Nephrectomy, pubmed-meshheading:1860716-Nitroprusside, pubmed-meshheading:1860716-Norepinephrine, pubmed-meshheading:1860716-Organ Size, pubmed-meshheading:1860716-Ornithine Decarboxylase, pubmed-meshheading:1860716-Polyamines, pubmed-meshheading:1860716-Putrescine, pubmed-meshheading:1860716-Rats, pubmed-meshheading:1860716-Rats, Inbred Strains, pubmed-meshheading:1860716-Serotonin, pubmed-meshheading:1860716-Spermidine, pubmed-meshheading:1860716-Spermine, pubmed-meshheading:1860716-Tail, pubmed-meshheading:1860716-Time Factors, pubmed-meshheading:1860716-Vasoconstriction
pubmed:year
1991
pubmed:articleTitle
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
pubmed:affiliation
Division of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't