|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2008-9-15
|
|
pubmed:abstractText |
Acceleration of the wound healing process by using angiogenic peptides has been demonstrated previously. Here we used select laminin-111 peptides, A13 and C16, from the laminin alpha1 and gamma1 chain, respectively, to test whether they are able to stimulate wound healing in a rat full thickness wound model. The 12-mer peptides C16 and A13 are highly angiogenic and bind to integrins alphavbeta3 and alpha5beta1. We show that A13 increases wound re-epithelialization as much as 17% over controls by day 4 and C16 increases coverage by 11%. Contraction of the treated wounds was increased as much as 11% for A13 and 8% for C16 at day 4. No differences were observed at day 7 with either peptide. The peptides also stimulated fibroblast migration in Boyden chamber assays. A13 increased cell migration as much as 2.4-fold on uncoated filters and as much as 16-fold on collagen type IV-coated filters over negative controls. Similarly, C16 also stimulated migration 1.8-fold on uncoated filters and as much as 12-fold on collagen-coated filters. A13 and C16 significantly decreased expression of the pro and active forms of matrix metalloproteinase 2 in foreskin fibroblasts indicating their role in collagen accumulation. We conclude that small bioactive angiogenic peptides can promote dermal wound healing and may offer a new class of stable and chemically manipulable therapeutics for wound healing.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-10189356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-10564562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-10697171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-10978889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-11083552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-12706114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-12714040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-1279183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-12809772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-1297987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-1376557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-15225204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-1524367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-15541073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-1569118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-15979864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-15993569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-17194893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-17276196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-1734035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-17719208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-2071570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-2491959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-7823364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-8447113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-8841427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-8867813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-8908195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-8930117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9105037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9194528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9211848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9232815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9410218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9531563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9551940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9645941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9665817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9777972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9852164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18603014-9872929
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1357-2725
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
40
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2771-80
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:18603014-Angiogenic Proteins,
pubmed-meshheading:18603014-Animals,
pubmed-meshheading:18603014-Cell Movement,
pubmed-meshheading:18603014-Cells, Cultured,
pubmed-meshheading:18603014-Collagen Type IV,
pubmed-meshheading:18603014-Dose-Response Relationship, Drug,
pubmed-meshheading:18603014-Endothelium,
pubmed-meshheading:18603014-Endothelium, Vascular,
pubmed-meshheading:18603014-Fibroblasts,
pubmed-meshheading:18603014-Humans,
pubmed-meshheading:18603014-Integrin alpha5beta1,
pubmed-meshheading:18603014-Integrin alphaVbeta3,
pubmed-meshheading:18603014-Laminin,
pubmed-meshheading:18603014-Matrix Metalloproteinase 2,
pubmed-meshheading:18603014-Neovascularization, Physiologic,
pubmed-meshheading:18603014-Rats,
pubmed-meshheading:18603014-Skin,
pubmed-meshheading:18603014-Time Factors,
pubmed-meshheading:18603014-Umbilical Veins,
pubmed-meshheading:18603014-Wound Healing
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Angiogenic laminin-derived peptides stimulate wound healing.
|
|
pubmed:affiliation |
Review Branch DERA, NHLBI, NIH, Bethesda, MD 20892-1857, USA.
|
|
pubmed:publicationType |
Journal Article
|
