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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute to increased rates of apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:BreitkopfKatjaK,
pubmed-author:CiuclanLoredanaL,
pubmed-author:DooleyStevenS,
pubmed-author:EhnertSabrinaS,
pubmed-author:GebhardtRolfR,
pubmed-author:GeierAndreasA,
pubmed-author:GodoyPatricioP,
pubmed-author:HamzaviJafarJ,
pubmed-author:IlkavetsIrynaI,
pubmed-author:KanzlerStephanS,
pubmed-author:MertensPeter RPR,
pubmed-author:UeberhamElkeE,
pubmed-author:WengHongleiH
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pubmed:issnType |
Electronic
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
642-59
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pubmed:meshHeading |
pubmed-meshheading:18602923-Animals,
pubmed-meshheading:18602923-Apoptosis,
pubmed-meshheading:18602923-Carbon Tetrachloride,
pubmed-meshheading:18602923-Cell Line,
pubmed-meshheading:18602923-Cell Survival,
pubmed-meshheading:18602923-Cell Transdifferentiation,
pubmed-meshheading:18602923-Cells, Cultured,
pubmed-meshheading:18602923-Collagen,
pubmed-meshheading:18602923-Disease Models, Animal,
pubmed-meshheading:18602923-Gene Expression Profiling,
pubmed-meshheading:18602923-Hepatitis B,
pubmed-meshheading:18602923-Hepatocytes,
pubmed-meshheading:18602923-Humans,
pubmed-meshheading:18602923-Liver Cirrhosis,
pubmed-meshheading:18602923-Male,
pubmed-meshheading:18602923-Mice,
pubmed-meshheading:18602923-Mice, Inbred C57BL,
pubmed-meshheading:18602923-Mice, Transgenic,
pubmed-meshheading:18602923-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18602923-Phenotype,
pubmed-meshheading:18602923-Schistosomiasis,
pubmed-meshheading:18602923-Smad7 Protein,
pubmed-meshheading:18602923-Time Factors,
pubmed-meshheading:18602923-Transforming Growth Factor beta
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pubmed:year |
2008
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pubmed:articleTitle |
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
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pubmed:affiliation |
Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany. steven.dooley@med.ma.uni-heidelberg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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