Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-9-8
pubmed:abstractText
We describe an uncommon thyroid tumor in a 56-year-old woman. The widely infiltrating, angioinvasive neoplasm, 5 cm in diameter, exhibited a peculiar architectural growth pattern characterized by follicles with round to oval epithelial tufts growing within, often supported by a fibrovascular core mimicking the renal glomerulus. Colloid-empty follicles, tubular or elongated, were lined by pseudostratified tall, columnar cells with clear cytoplasm. Nuclei were round to oval, with evenly distributed, slightly coarse chromatin. Tumor cells were positive for thyroid transcription factor-1, thyroperoxidase, thyroglobulin, cytokeratin 18, Hector Battifora mesothelial cell, and vimentin. Scattered cells positive for S100, Wilms tumor 1 (WT1), and cytokeratins AE1/AE3 were found, with no reaction detected for cytokeratins 34betaE12, 5/6, 7, 19, or 20. There were PAX8-PPARgamma rearrangement and N-RAS mutation. No mutations were found for APC or BRAF genes, nor were RET/PTC rearrangements detected. Because of the distinctive histologic features, we propose naming this tumor follicular thyroid carcinoma with an unusual glomeruloid pattern of growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/HBME-1 antigen, http://linkedlifedata.com/resource/pubmed/chemical/Iodide Peroxidase, http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes, http://linkedlifedata.com/resource/pubmed/chemical/Keratin-18, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PAX8 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma, http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological, http://linkedlifedata.com/resource/pubmed/chemical/Vimentin, http://linkedlifedata.com/resource/pubmed/chemical/thyroid nuclear factor 1
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1532-8392
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1540-7
pubmed:meshHeading
pubmed-meshheading:18602667-Adenocarcinoma, Follicular, pubmed-meshheading:18602667-Cell Nucleus, pubmed-meshheading:18602667-DNA, Neoplasm, pubmed-meshheading:18602667-Female, pubmed-meshheading:18602667-Gene Rearrangement, pubmed-meshheading:18602667-Genes, ras, pubmed-meshheading:18602667-Humans, pubmed-meshheading:18602667-Iodide Peroxidase, pubmed-meshheading:18602667-Iodine Radioisotopes, pubmed-meshheading:18602667-Keratin-18, pubmed-meshheading:18602667-Middle Aged, pubmed-meshheading:18602667-Mutation, pubmed-meshheading:18602667-Neoplasm Invasiveness, pubmed-meshheading:18602667-Nuclear Proteins, pubmed-meshheading:18602667-PPAR gamma, pubmed-meshheading:18602667-Paired Box Transcription Factors, pubmed-meshheading:18602667-Thyroid Neoplasms, pubmed-meshheading:18602667-Thyroidectomy, pubmed-meshheading:18602667-Transcription Factors, pubmed-meshheading:18602667-Tumor Markers, Biological, pubmed-meshheading:18602667-Vimentin
pubmed:year
2008
pubmed:articleTitle
Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth.
pubmed:affiliation
Department of Pathology, Clinical University Hospital, SERGAS, University of Santiago de Compostela, 15706 Santiago de Compostela, Galicia, Spain. apjocame@usc.es
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't