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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-9-10
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pubmed:abstractText |
A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-6246
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-42
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pubmed:meshHeading |
pubmed-meshheading:18602445-Adolescent,
pubmed-meshheading:18602445-Adult,
pubmed-meshheading:18602445-Brain,
pubmed-meshheading:18602445-Brain Mapping,
pubmed-meshheading:18602445-Case-Control Studies,
pubmed-meshheading:18602445-Female,
pubmed-meshheading:18602445-Genotype,
pubmed-meshheading:18602445-Histidine,
pubmed-meshheading:18602445-Humans,
pubmed-meshheading:18602445-Linkage Disequilibrium,
pubmed-meshheading:18602445-Male,
pubmed-meshheading:18602445-Memory,
pubmed-meshheading:18602445-Neuropsychological Tests,
pubmed-meshheading:18602445-Polymorphism, Genetic,
pubmed-meshheading:18602445-Polymorphism, Single Nucleotide,
pubmed-meshheading:18602445-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:18602445-Tyrosine,
pubmed-meshheading:18602445-Verbal Learning,
pubmed-meshheading:18602445-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants.
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pubmed:affiliation |
Division of Molecular Psychology, University of Basel, Basel, Switzerland. jessica.sigmund@unibas.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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