Source:http://linkedlifedata.com/resource/pubmed/id/18601993
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-8-18
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| pubmed:abstractText |
In the course of screening plants used in Korean folk medicine as memory enhancers, a 70% ethanol extract of tuber from Corydalis turtschaninovii Besser (Papaveraceae) showed significant acetylcholinesterase (AChE) inhibitory activity. Repeated column chromatography led to the isolation of a new aporphine alkaloid, oxoglaucidaline (9), and a new protoberberine, pseudodehydrocorydaline (13) together with 14 known compounds (1-8, 10-12, and 14-16). The chemical structures of isolated compounds were elucidated base on extensive 1D and 2D NMR spectroscopic data. Compounds 1-16 were investigated in vitro for their anti-cholinesterase activity using the mice cortex AChE enzyme. In further study, the anti-amnesic activities of pseudoberberine (16) in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) were examined. This alkaloid (5.0 mg/kg, p.o.) administration significantly reversed cognitive impairments in mice by passive avoidance test (P<0.05). It also reduced escape latencies in training trials and prolonged swimming times in the target quadrant during the probe trial in the water maze task (P<0.05). These results indicated that Corydalis turtschaninovii due to its alkaloids have anti-cholinesterase activity and pseudoberberine and other alkaloids have anti-amnesic activities that may be useful for cognitive impairment treatment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0378-8741
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
2
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| pubmed:volume |
119
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
74-80
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| pubmed:meshHeading |
pubmed-meshheading:18601993-Acetylcholinesterase,
pubmed-meshheading:18601993-Alkaloids,
pubmed-meshheading:18601993-Amnesia,
pubmed-meshheading:18601993-Animals,
pubmed-meshheading:18601993-Avoidance Learning,
pubmed-meshheading:18601993-Berberine,
pubmed-meshheading:18601993-Cerebral Cortex,
pubmed-meshheading:18601993-Cholinesterase Inhibitors,
pubmed-meshheading:18601993-Cognition Disorders,
pubmed-meshheading:18601993-Corydalis,
pubmed-meshheading:18601993-Korea,
pubmed-meshheading:18601993-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18601993-Male,
pubmed-meshheading:18601993-Maze Learning,
pubmed-meshheading:18601993-Medicine, East Asian Traditional,
pubmed-meshheading:18601993-Mice,
pubmed-meshheading:18601993-Mice, Inbred ICR,
pubmed-meshheading:18601993-Plant Tubers,
pubmed-meshheading:18601993-Rats,
pubmed-meshheading:18601993-Rats, Sprague-Dawley
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| pubmed:year |
2008
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| pubmed:articleTitle |
Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii.
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| pubmed:affiliation |
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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