Linked Life Data

18600549

Source:http://linkedlifedata.com/resource/pubmed/id/18600549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-7-7
pubmed:abstractText
Genetic variation in thiopurine S-methyltransferase (TPMT) is a major factors for wide variation in the metabolism and safety of thiopurine drugs. We investigated the frequency of functional gene polymorphisms in 396 patients with inflammatory bowel disease and 300 healthy subjects. Frequencies of functionally deficient alleles TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3B in the patient group were 0.1%, 4.3%, 0.1%, and 0.4%, respectively, and were similar to those of healthy subjects in the Czech population. Our results provide necessary information for pharmacoeconomic studies in the Czech Republic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1532-2335
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
835-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease.
pubmed:affiliation
Clinical Pharmacology Unit, Department of Pharmacology, First Faculty of Medicine Charles University, General Teaching Hospital, Prague, Czech Republic. oslan@lf1.cuni.cz
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't