pubmed-article:18599786 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18599786 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:18599786 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:18599786 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
pubmed-article:18599786 | lifeskim:mentions | umls-concept:C0004391 | lld:lifeskim |
pubmed-article:18599786 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
pubmed-article:18599786 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
pubmed-article:18599786 | pubmed:issue | 5885 | lld:pubmed |
pubmed-article:18599786 | pubmed:dateCreated | 2008-7-7 | lld:pubmed |
pubmed-article:18599786 | pubmed:abstractText | After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized. We found that autophagy, a process for the degradation of cytoplasmic constituents in the lysosome, plays a critical role during this period. Autophagy was triggered by fertilization and up-regulated in early mouse embryos. Autophagy-defective oocytes derived from oocyte-specific Atg5 (autophagy-related 5) knockout mice failed to develop beyond the four- and eight-cell stages if they were fertilized by Atg5-null sperm, but could develop if they were fertilized by wild-type sperm. Protein synthesis rates were reduced in the autophagy-null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals. | lld:pubmed |
pubmed-article:18599786 | pubmed:language | eng | lld:pubmed |
pubmed-article:18599786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18599786 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:18599786 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18599786 | pubmed:month | Jul | lld:pubmed |
pubmed-article:18599786 | pubmed:issn | 1095-9203 | lld:pubmed |
pubmed-article:18599786 | pubmed:author | pubmed-author:YamamotoAkits... | lld:pubmed |
pubmed-article:18599786 | pubmed:author | pubmed-author:MizushimaNobo... | lld:pubmed |
pubmed-article:18599786 | pubmed:author | pubmed-author:KumaAkikoA | lld:pubmed |
pubmed-article:18599786 | pubmed:author | pubmed-author:MurakamiMirei... | lld:pubmed |
pubmed-article:18599786 | pubmed:author | pubmed-author:TsukamotoSato... | lld:pubmed |
pubmed-article:18599786 | pubmed:author | pubmed-author:KishiChiekoC | lld:pubmed |
pubmed-article:18599786 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:18599786 | pubmed:day | 4 | lld:pubmed |
pubmed-article:18599786 | pubmed:volume | 321 | lld:pubmed |
pubmed-article:18599786 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18599786 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18599786 | pubmed:pagination | 117-20 | lld:pubmed |
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pubmed-article:18599786 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:18599786 | pubmed:articleTitle | Autophagy is essential for preimplantation development of mouse embryos. | lld:pubmed |
pubmed-article:18599786 | pubmed:affiliation | Department of Physiology and Cell Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. | lld:pubmed |
pubmed-article:18599786 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18599786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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