| pubmed-article:18598300 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C0143630 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C0025201 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C1513094 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18598300 | lifeskim:mentions | umls-concept:C0061200 | lld:lifeskim |
| pubmed-article:18598300 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18598300 | pubmed:dateCreated | 2008-7-7 | lld:pubmed |
| pubmed-article:18598300 | pubmed:abstractText | Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of generalized vitiligo. Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that can be suppressed by norepinephrine. This study addresses the action and mechanism of geniposide enhancing melanogenesis in norepinephrine-exposed normal human epidermal melanocyte. Flow cytometry results from this study exhibited the augmentation effect of geniposide on production of c-kit receptor by norepinephrine-exposed normal human epidermal melanocyte. However, geniposide did not affect the production of stem cell factor by norepinephrine-exposed normal human epidermal keratinocyte assessed by cellular enzyme-linked immunosorbent assay (ELISA). ELISA indicated that at the presence of stem cell factor, geniposide was capable of elevating the level of extracellular signal-regulated kinase 1/2 phosphorylation within norepinephrine-exposed normal human epidermal melanocyte, which is known to be involved in stem cell factor/c-kit downstream signalling. And inhibition of c-kit with inhibitory antibody K44.2 completely blocked the increase in geniposide-stimulated extracellular signal-regulated kinase 1/2 phosphorylation. In addition, spectrophotometry demonstrated the enhancement effect of geniposide on melanogenesis (tyrosinase activity and melanin production) in norepinephrine-exposed normal human epidermal melanocyte at the presence of stem cell factor, which was blocked by c-kit inhibitory antibody K44.2. Data from this study suggest that geniposide can enhance melanogenesis by stem cell factor/c-kit signalling in which the expression of c-kit receptor is augmented in norepinephrine-exposed normal human epidermal melanocyte. | lld:pubmed |
| pubmed-article:18598300 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18598300 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18598300 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18598300 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18598300 | pubmed:issn | 1742-7843 | lld:pubmed |
| pubmed-article:18598300 | pubmed:author | pubmed-author:WangHai-YanHY | lld:pubmed |
| pubmed-article:18598300 | pubmed:author | pubmed-author:WeiLanL | lld:pubmed |
| pubmed-article:18598300 | pubmed:author | pubmed-author:WangKe-YuKY | lld:pubmed |
| pubmed-article:18598300 | pubmed:author | pubmed-author:LanWen-JunWJ | lld:pubmed |
| pubmed-article:18598300 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18598300 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:18598300 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18598300 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18598300 | pubmed:pagination | 88-93 | lld:pubmed |
| pubmed-article:18598300 | pubmed:dateRevised | 2010-6-10 | lld:pubmed |
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| pubmed-article:18598300 | pubmed:meshHeading | pubmed-meshheading:18598300... | lld:pubmed |
| pubmed-article:18598300 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18598300 | pubmed:articleTitle | Geniposide enhances melanogenesis by stem cell factor/c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte. | lld:pubmed |
| pubmed-article:18598300 | pubmed:affiliation | Laboratory for Drug Discovery, Shandong Institute of Light Industry, Jinan, China. lanwenjun0522@sina.com | lld:pubmed |
| pubmed-article:18598300 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18598300 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18598300 | lld:pubmed |
