rdf:type |
|
lifeskim:mentions |
umls-concept:C0026051,
umls-concept:C0183683,
umls-concept:C0205208,
umls-concept:C0205554,
umls-concept:C0220781,
umls-concept:C0344211,
umls-concept:C0599124,
umls-concept:C1171411,
umls-concept:C1269765,
umls-concept:C1317973,
umls-concept:C1521721,
umls-concept:C1704332,
umls-concept:C1883254,
umls-concept:C2936295
|
pubmed:issue |
15
|
pubmed:dateCreated |
2008-7-28
|
pubmed:abstractText |
Small libraries of di-, tri-, and tetragalactosyl clusters were efficiently synthesized using combinatorial methodology, on solid support, by click chemistry assisted by microwaves, starting from different poly alkyne DNA-based scaffolds and two galactosyl azide derivatives. The scaffold was synthesized by standard DNA solid-supported phosphoramidite chemistry using a novel alkyne phosphoramidite and an alkyne solid support. The proportion of each glycocluster in a library was modulated using different molar ratios of both galactose azides.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1520-6904
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
73
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
6014-7
|
pubmed:meshHeading |
pubmed-meshheading:18598084-Acetylation,
pubmed-meshheading:18598084-Azides,
pubmed-meshheading:18598084-Chromatography, High Pressure Liquid,
pubmed-meshheading:18598084-Combinatorial Chemistry Techniques,
pubmed-meshheading:18598084-Esters,
pubmed-meshheading:18598084-Galactose,
pubmed-meshheading:18598084-Microwaves,
pubmed-meshheading:18598084-Molecular Structure,
pubmed-meshheading:18598084-Phosphorus Compounds,
pubmed-meshheading:18598084-Spectrometry, Mass, Matrix-Assisted Laser...
|
pubmed:year |
2008
|
pubmed:articleTitle |
Combinatorial and automated synthesis of phosphodiester galactosyl cluster on solid support by click chemistry assisted by microwaves.
|
pubmed:affiliation |
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier 1, Place Eugène Bataillon, CC1704, 34095 Montpellier Cedex 5, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|