18597859

Source:http://linkedlifedata.com/resource/pubmed/id/18597859

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019409, umls-concept:C0086418, umls-concept:C0295352, umls-concept:C1522634
pubmed:issue	9
pubmed:dateCreated	2008-12-15
pubmed:abstractText	The 5-hydroxytryptamine 3 (5-HT3) receptor is expressed widely in the central and peripheral nervous systems, where it mediates or modulates a wide range of physiological processes. The receptor is targeted by drugs administered for nausea and/or emesis and irritable bowel syndrome and has been proposed as a potential drug target in various psychiatric disorders. The 5-HT3 receptor is a pentameric ligand-gated ion channel and belongs to the Cys-loop receptor family. In contrast to the immense heterogeneity characterizing other Cysloop receptors, native 5-HT3 receptors historically have been considered a much more homogenous receptor population. However, the recent discovery of additional 5-HT3 subunits and the dawning realization that central and peripheral 5-HT3 receptor populations might comprise several subtypes characterized by distinct functional properties has emphasized the complexity of human 5-HT3 receptor signaling. In this review potential implications of these findings and of the entirely new layer of interindividual diversity introduced to the 5-HT3 receptor system by genetic variations will be outlined.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7906158
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT3
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0165-6147
pubmed:author	pubmed-author:Bräuner-OsborneHansH, pubmed-author:DaviesPaul APA, pubmed-author:JensenAnders AAA, pubmed-author:KrzywkowskiKarenK
pubmed:issnType	Print
pubmed:volume	29
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	437-44
pubmed:meshHeading	pubmed-meshheading:18597859-Humans, pubmed-meshheading:18597859-Receptors, Serotonin, 5-HT3
pubmed:year	2008
pubmed:articleTitle	3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.
pubmed:affiliation	Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. aaj@farma.ku.dk
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't