| pubmed-article:18597688 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0109317 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1705767 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0040682 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1366882 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1150579 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1333340 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1705791 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1418540 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18597688 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:18597688 | pubmed:dateCreated | 2008-7-18 | lld:pubmed |
| pubmed-article:18597688 | pubmed:abstractText | Signaling downstream of Ras is mediated by three major pathways, Raf/ERK, phosphatidylinositol 3 kinase (PI3K), and Ral guanine nucleotide exchange factor (RalGEF). Ras signal transduction pathways play an important role in breast cancer progression, as evidenced by the frequent over-expression of the Ras-activating epidermal growth factor receptors EGFR and ErbB2. Here we investigated which signal transduction pathways downstream of Ras contribute to EGFR-dependent transformation of telomerase-immortalized mammary epithelial cells HME16C. Furthermore, we examined whether a highly transcriptionally regulated ERK pathway target, PHLDA1 (TDAG51), suggested to be a tumor suppressor in breast cancer and melanoma, might modulate the transformation process. | lld:pubmed |
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| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18597688 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18597688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18597688 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18597688 | pubmed:issn | 1471-2407 | lld:pubmed |
| pubmed-article:18597688 | pubmed:author | pubmed-author:LiuZhaoZ | lld:pubmed |
| pubmed-article:18597688 | pubmed:author | pubmed-author:KellyKathleen... | lld:pubmed |
| pubmed-article:18597688 | pubmed:author | pubmed-author:OberstMichael... | lld:pubmed |
| pubmed-article:18597688 | pubmed:author | pubmed-author:WardYvonaY | lld:pubmed |
| pubmed-article:18597688 | pubmed:author | pubmed-author:YinJuan... | lld:pubmed |
| pubmed-article:18597688 | pubmed:author | pubmed-author:BebermanStace... | lld:pubmed |
| pubmed-article:18597688 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18597688 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:18597688 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18597688 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18597688 | pubmed:pagination | 189 | lld:pubmed |
| pubmed-article:18597688 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18597688 | pubmed:meshHeading | pubmed-meshheading:18597688... | lld:pubmed |
| pubmed-article:18597688 | pubmed:meshHeading | pubmed-meshheading:18597688... | lld:pubmed |
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| pubmed-article:18597688 | pubmed:meshHeading | pubmed-meshheading:18597688... | lld:pubmed |
| pubmed-article:18597688 | pubmed:meshHeading | pubmed-meshheading:18597688... | lld:pubmed |
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| pubmed-article:18597688 | pubmed:meshHeading | pubmed-meshheading:18597688... | lld:pubmed |
| pubmed-article:18597688 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18597688 | pubmed:articleTitle | TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation. | lld:pubmed |
| pubmed-article:18597688 | pubmed:affiliation | Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 1066, Bethesda, MD 20892, USA. michaeloberst@gmail.com | lld:pubmed |
| pubmed-article:18597688 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18597688 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
