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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0009402,
umls-concept:C0013216,
umls-concept:C0016360,
umls-concept:C0040085,
umls-concept:C0058126,
umls-concept:C0178785,
umls-concept:C0205210,
umls-concept:C0439807,
umls-concept:C0683317,
umls-concept:C0728940,
umls-concept:C1151895,
umls-concept:C1522673
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pubmed:dateCreated |
2008-7-31
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pubmed:abstractText |
A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports have examined thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase (DPD) in unresectable or metastatic cases, therefore it is unclear whether the activity of these enzymes is of prognostic value in colorectal cancer patients treated with radical resection and adjuvant chemotherapy with 5-FU.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-10473070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-10473077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-10499634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-10690528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-10791849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-11527696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-11919227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-12494248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-12576451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-12720098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-14519634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-14562021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-14752076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-15015608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-1717130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-17179731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18597678-3286830
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18597678-Aged,
pubmed-meshheading:18597678-Colorectal Neoplasms,
pubmed-meshheading:18597678-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:18597678-Drug Therapy,
pubmed-meshheading:18597678-Enzyme Activation,
pubmed-meshheading:18597678-Female,
pubmed-meshheading:18597678-Fluorouracil,
pubmed-meshheading:18597678-Humans,
pubmed-meshheading:18597678-Male,
pubmed-meshheading:18597678-Middle Aged,
pubmed-meshheading:18597678-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:18597678-Orotate Phosphoribosyltransferase,
pubmed-meshheading:18597678-Prognosis,
pubmed-meshheading:18597678-Survival Analysis,
pubmed-meshheading:18597678-Thymidylate Synthase
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pubmed:year |
2008
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pubmed:articleTitle |
Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy.
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pubmed:affiliation |
Department of Surgery, National Kochi Hospital, Kochi, Japan. masa1192@tokushima-med.jrc.or.jp
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pubmed:publicationType |
Journal Article
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