|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-10-16
|
|
pubmed:abstractText |
Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of vascular homeostasis leading to reduced relaxation, hypertrophy, and a higher risk of thrombotic events. These effects can be explained by a reduction in free bioavailable nitric oxide that is inactivated by an age-dependent increase in superoxide formation. In the present study, mitochondria as a source of reactive oxygen species (ROS) and the contribution of manganese superoxide dismutase (MnSOD, SOD-2) and aldehyde dehydrogenase (ALDH-2) were investigated.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0008-6363
|
|
pubmed:author |
pubmed-author:BürkleAlexanderA,
pubmed-author:BachschmidMarkus MichaelMM,
pubmed-author:DaiberAndreasA,
pubmed-author:HortmannMarcusM,
pubmed-author:KawamotoToshihiroT,
pubmed-author:KienhöferJoachimJ,
pubmed-author:MüllerJohannaJ,
pubmed-author:MünzelThomasT,
pubmed-author:OelzeMatthiasM,
pubmed-author:Scharffetter-KochanekKarinK,
pubmed-author:SchuhmacherSwenjaS,
pubmed-author:SchulzEberhardE,
pubmed-author:TreiberNicolaiN,
pubmed-author:WenzelPhilipP
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
80
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
280-9
|
|
pubmed:meshHeading |
pubmed-meshheading:18596060-Age Factors,
pubmed-meshheading:18596060-Aging,
pubmed-meshheading:18596060-Aldehyde Dehydrogenase,
pubmed-meshheading:18596060-Animals,
pubmed-meshheading:18596060-Aorta,
pubmed-meshheading:18596060-DNA, Mitochondrial,
pubmed-meshheading:18596060-DNA Damage,
pubmed-meshheading:18596060-Dose-Response Relationship, Drug,
pubmed-meshheading:18596060-Endothelium, Vascular,
pubmed-meshheading:18596060-Male,
pubmed-meshheading:18596060-Mice,
pubmed-meshheading:18596060-Mice, Inbred C57BL,
pubmed-meshheading:18596060-Mice, Knockout,
pubmed-meshheading:18596060-Mitochondria, Heart,
pubmed-meshheading:18596060-Muscle, Smooth, Vascular,
pubmed-meshheading:18596060-Oxidative Stress,
pubmed-meshheading:18596060-Reactive Oxygen Species,
pubmed-meshheading:18596060-Superoxide Dismutase,
pubmed-meshheading:18596060-Vasodilation,
pubmed-meshheading:18596060-Vasodilator Agents
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction.
|
|
pubmed:affiliation |
Second Medical Clinic, Department of Cardiology, Johannes Gutenberg University, Mainz, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
