Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1977-9-29
|
| pubmed:abstractText |
Acenocoumarol, to which a 14C-labeled internal standard has been added, is extracted at pH 4 into ethyl acetate-heptane (20:80 v/v), back-extracted into aqueous sodium hydroxide solution after solvent washing with a pH 7 buffer, and reextracted after acidification in the solvent mixture. It is then acetylated with 3H-acetic anhydride. The acenocoumarol acetyl derivative is separated from the metabolite derivatives by TLC, and its radioactivity is measured. The method is specific and sensitive to a concentration of 8 ng/ml.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-3549
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
997-1000
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:18595-Acenocoumarol,
pubmed-meshheading:18595-Acetylation,
pubmed-meshheading:18595-Carbon Radioisotopes,
pubmed-meshheading:18595-Chromatography, Thin Layer,
pubmed-meshheading:18595-Hydrogen-Ion Concentration,
pubmed-meshheading:18595-Isotope Labeling,
pubmed-meshheading:18595-Kinetics,
pubmed-meshheading:18595-Methods,
pubmed-meshheading:18595-Tritium
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Determination of acenocoumarol in plasma and urine by double radioisotope derivative analysis.
|
| pubmed:publicationType |
Journal Article
|