|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1991-8-29
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|
pubmed:abstractText |
Selective and marked 3-hydroxylase deficiency of lidocaine and its N-deethylated metabolite, MEGX, were observed in male and female DA rats. These findings suggest that cytochrome P450 isozymes metabolizing debrisoquine may be involved in the 3-hydroxylations of lidocaine and MEGX in rats and humans.
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|
pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-2952
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
693-5
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:1859470-Animals,
pubmed-meshheading:1859470-Cytochrome P-450 CYP2D6,
pubmed-meshheading:1859470-Cytochrome P-450 Enzyme System,
pubmed-meshheading:1859470-Disease Models, Animal,
pubmed-meshheading:1859470-Female,
pubmed-meshheading:1859470-Hydroxylation,
pubmed-meshheading:1859470-Lidocaine,
pubmed-meshheading:1859470-Male,
pubmed-meshheading:1859470-Microsomes, Liver,
pubmed-meshheading:1859470-Mixed Function Oxygenases,
pubmed-meshheading:1859470-Rats,
pubmed-meshheading:1859470-Rats, Inbred Strains
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats.
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|
pubmed:affiliation |
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
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|
pubmed:publicationType |
Journal Article,
Comparative Study
|
