|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2008-7-2
|
|
pubmed:abstractText |
Previously published results from a randomized phase III study of pemetrexed plus cisplatin in patients with malignant pleural mesothelioma (MPM) demonstrated a significant survival benefit and higher response rate compared with cisplatin. Although pemetrexed was under review by regulatory agencies, an International Expanded Access Program (EAP) provided more than 3000 mesothelioma patients with access to single-agent pemetrexed or pemetrexed in combination with cisplatin or carboplatin in 13 countries. This manuscript reports the safety and efficacy data from the nonrandomized open-label study in chemonaïve patients receiving pemetrexed plus platinum under the EAP.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1556-1380
|
|
pubmed:author |
pubmed-author:BaasPaulP,
pubmed-author:BlatterJohannesJ,
pubmed-author:EberhardtWilfriedW,
pubmed-author:KarthausMeinolfM,
pubmed-author:LiuYushanY,
pubmed-author:ManegoldChristianC,
pubmed-author:NackaertsKristiaanK,
pubmed-author:O'BrienMary EME,
pubmed-author:Paz-AresLuisL,
pubmed-author:RipocheVeroniqueV,
pubmed-author:SantoroArmandoA,
pubmed-author:StahelRolf ARA,
pubmed-author:SundstromSteinS,
pubmed-author:Visseren-GrulCarla MCM
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
756-63
|
|
pubmed:meshHeading |
pubmed-meshheading:18594322-Adult,
pubmed-meshheading:18594322-Aged,
pubmed-meshheading:18594322-Aged, 80 and over,
pubmed-meshheading:18594322-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18594322-Carboplatin,
pubmed-meshheading:18594322-Cisplatin,
pubmed-meshheading:18594322-Disease Progression,
pubmed-meshheading:18594322-Female,
pubmed-meshheading:18594322-Folic Acid Antagonists,
pubmed-meshheading:18594322-Glutamates,
pubmed-meshheading:18594322-Guanine,
pubmed-meshheading:18594322-Humans,
pubmed-meshheading:18594322-Male,
pubmed-meshheading:18594322-Mesothelioma,
pubmed-meshheading:18594322-Middle Aged,
pubmed-meshheading:18594322-Pleural Neoplasms,
pubmed-meshheading:18594322-Survival Rate,
pubmed-meshheading:18594322-Thymidylate Synthase
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Pemetrexed plus cisplatin or pemetrexed plus carboplatin for chemonaïve patients with malignant pleural mesothelioma: results of the International Expanded Access Program.
|
|
pubmed:affiliation |
Istituto Clinico Humanitas, Rozzano, Italy. armando.santoro@humanitas.it
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
