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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2008-7-2
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pubmed:abstractText |
Increased expression and/or activation of epidermal growth factor receptor (EGFR) is associated with tumor progression and poor prognosis in many cancers, including head and neck squamous cell carcinoma (HNSCC). Src family kinases, including c-Src, mediate a variety of intracellular or extracellular signals that contribute to tumor formation and progression. This study was undertaken to elucidate the role of c-Src in the growth and invasion of HNSCC and to determine the effects of combined targeting of EGFR and Src kinases in HNSCC cell lines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ChoiSeung-HoSH,
pubmed-author:EgloffAnn MarieAM,
pubmed-author:FreilinoMariaM,
pubmed-author:GoodingWilliam EWE,
pubmed-author:GrandisJennifer RJR,
pubmed-author:KoppikarPriyaP,
pubmed-author:NozawaHiroshiH,
pubmed-author:SAIDM FMF,
pubmed-author:SiegfriedJill MJM,
pubmed-author:SuzukiShinsukeS,
pubmed-author:ThomasSufi MSM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4284-91
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18594011-Carcinoma, Squamous Cell,
pubmed-meshheading:18594011-Cell Line, Tumor,
pubmed-meshheading:18594011-Cell Proliferation,
pubmed-meshheading:18594011-Disease Progression,
pubmed-meshheading:18594011-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18594011-Genes, src,
pubmed-meshheading:18594011-Genetic Vectors,
pubmed-meshheading:18594011-Head and Neck Neoplasms,
pubmed-meshheading:18594011-Humans,
pubmed-meshheading:18594011-Inhibitory Concentration 50,
pubmed-meshheading:18594011-Neoplasm Invasiveness,
pubmed-meshheading:18594011-Phosphorylation,
pubmed-meshheading:18594011-Prognosis,
pubmed-meshheading:18594011-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18594011-src-Family Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma.
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pubmed:affiliation |
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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