Source:http://linkedlifedata.com/resource/pubmed/id/18593943
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
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| pubmed:dateCreated |
2008-7-2
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| pubmed:abstractText |
Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer. In a search for additional prognostic motifs, we analyzed the gene expression patterns of 200 tumors of patients who were not treated by systemic therapy after surgery using a discovery approach. After performing hierarchical cluster analysis, we identified coregulated genes related to the biological process of proliferation, steroid hormone receptor expression, as well as B-cell and T-cell infiltration. We calculated metagenes as a surrogate for all genes contained within a particular cluster and visualized the relative expression in relation to time to metastasis with principal component analysis. Distinct patterns led to the hypothesis of a prognostic role of the immune system in tumors with high expression of proliferation-associated genes. In multivariate Cox regression analysis, the proliferation metagene showed a significant association with metastasis-free survival of the whole discovery cohort [hazard ratio (HR), 2.20; 95% confidence interval (95% CI), 1.40-3.46]. The B-cell metagene showed additional independent prognostic information in carcinomas with high proliferative activity (HR, 0.66; 95% CI, 0.46-0.97). A prognostic influence of the B-cell metagene was independently confirmed by multivariate analysis in a first validation cohort enriched for high-grade tumors (n = 286; HR, 0.78; 95% CI, 0.62-0.98) and a second validation cohort enriched for younger patients (n = 302; HR, 0.83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1538-7445
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
68
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
5405-13
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| pubmed:meshHeading |
pubmed-meshheading:18593943-Adult,
pubmed-meshheading:18593943-Aged,
pubmed-meshheading:18593943-Aged, 80 and over,
pubmed-meshheading:18593943-Antibody Formation,
pubmed-meshheading:18593943-Breast Neoplasms,
pubmed-meshheading:18593943-Carcinoma,
pubmed-meshheading:18593943-Cell Proliferation,
pubmed-meshheading:18593943-Cluster Analysis,
pubmed-meshheading:18593943-Cohort Studies,
pubmed-meshheading:18593943-Female,
pubmed-meshheading:18593943-Gene Expression Profiling,
pubmed-meshheading:18593943-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18593943-Genes, Neoplasm,
pubmed-meshheading:18593943-Humans,
pubmed-meshheading:18593943-Lymph Nodes,
pubmed-meshheading:18593943-Lymphatic Metastasis,
pubmed-meshheading:18593943-Middle Aged,
pubmed-meshheading:18593943-Neutrophil Infiltration,
pubmed-meshheading:18593943-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18593943-Prognosis
|
| pubmed:year |
2008
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| pubmed:articleTitle |
The humoral immune system has a key prognostic impact in node-negative breast cancer.
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| pubmed:affiliation |
Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany.
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| pubmed:publicationType |
Journal Article,
Multicenter Study,
Validation Studies
|