Linked Life Data

18593343

Source:http://linkedlifedata.com/resource/pubmed/id/18593343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-8-1
pubmed:abstractText
We assessed the utility of the modified Kigali combined (MKC) staging system for predicting survival in HIV-infected Zambian adults in a prospective, longitudinal, open cohort. From 1995 to 2004, HIV-discordant couples (one HIV-infected partner and one HIV-negative partner) were recruited from couples' voluntary counseling and testing centers in Lusaka, Zambia and followed at 3-month intervals. MKC stage, which incorporates clinical stage with erythrocyte sedimentation rate (ESR), hematocrit, and body mass index (BMI), was determined at enrollment. Kaplan-Meier survival and Cox proportional hazard methods were used to calculate median survival and relative hazards. We enrolled 1479 HIV-discordant couples with a combined 7305 person-years of follow-up. Among HIV-infected participants over the 9-year study period, there were 333 confirmed deaths. The time to 50% mortality was 8.5 years with MKC stage 1 and 2 disease compared to 3.7 years with MKC stage 4 disease at enrollment. Survival rates at 3 years were 85% with MKC stage 1 and 2 disease, 74% with MKC stage 3 disease, and 51% with MKC stage 4 disease. A total of 275 HIV-negative partners seroconverted during follow-up. In comparison, survival rates at 3 years were 94% for HIV-negative participants and 92% for participants who seroconverted during follow-up. In multivariate analysis, MKC stage 4 disease (HR = 3.7, 95% CI = 2.7-5.0) remained a strong predictor of mortality. Incorporating ESR, hematocrit, and BMI with clinical staging is a powerful, low-cost tool to identify HIV-infected adults at high risk for mortality.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1931-8405
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
919-24
pubmed:dateRevised
2010-9-1
pubmed:meshHeading
pubmed-meshheading:18593343-Adult, pubmed-meshheading:18593343-Antiretroviral Therapy, Highly Active, pubmed-meshheading:18593343-Blood Sedimentation, pubmed-meshheading:18593343-Body Mass Index, pubmed-meshheading:18593343-Cohort Studies, pubmed-meshheading:18593343-Disease-Free Survival, pubmed-meshheading:18593343-Family Characteristics, pubmed-meshheading:18593343-Female, pubmed-meshheading:18593343-HIV Infections, pubmed-meshheading:18593343-HIV-1, pubmed-meshheading:18593343-HIV-2, pubmed-meshheading:18593343-Hematocrit, pubmed-meshheading:18593343-Humans, pubmed-meshheading:18593343-Male, pubmed-meshheading:18593343-Probability, pubmed-meshheading:18593343-Risk Factors, pubmed-meshheading:18593343-Survival Rate, pubmed-meshheading:18593343-Urban Population, pubmed-meshheading:18593343-Zambia
pubmed:year
2008
pubmed:articleTitle
Modified Kigali combined staging predicts risk of mortality in HIV-infected adults in Lusaka, Zambia.
pubmed:affiliation
Division of Infectious Diseases, Emory University, Atlanta, Georgia 30030, USA. pjpeters@cdc.gov
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural